“The deeper layers of your skin are working at night to build new collagen, which makes your complexion smooth, and firm,” Dr. Bowe explains. Pro tip: Keep wrinkles at bay by sleeping on your back rather than on your side or facedown, suggests Jesleen Ahluwalia, M.D., a New York dermatologist. “Repeated pressure on the skin that causes creases can lead to set-in lines over time,” she adds.